Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 12
Release date: Jul 17 2012
Last update date: Jul 26 2018
Access: Public
Diseases: Myeloproliferative Disorders
Dataset link The HDAC inhibitor Givinostat modulates key hematopoietic genes in JAK2V617F cells, affecting proliferation, differentiation and apoptosis

Experimental Protocol


Gene expression profiling, JAK2V617F cell lines, ITF2357. This series of microarray experiments contains the gene expression profiles of independent triplicates of HEL and UKE1 erythroleukemia cell lines bearing the JAK2V617F mutation, before and after ITF2357 treatment. 100 nanograms of total RNA were processed, and fragmented biotin-labelled single-stranded DNA target was hybridized to the GeneChip® Gene 1.0 ST array following the Affymetrix manufacturer's instructions.

Repositories


GEO

GSE27615

ArrayExpress

E-GEOD-27615

BioProject

PRJNA138267

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Contact


Luca Agnelli
Antonino Neri