Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 8
Release date: Apr 3 2013
Last update date: May 7 2013
Access: Public
Diseases: Encephalomyelitis, Autoimmune, Experimental, Hereditary Central Nervous System Demyelinating Diseases
Dataset link Gene Expression Changes in the Spinal Cords of Lewis Rats with Myelin Basic Protein-Induced Experimental Autoimmune Encephalomyelitis (EAE)

Experimental Protocol


8 total RNA samples were prepared. A two way ANOVA comparison carried out in Partek Genomics Suite was used to detect gene transcripts for which the expression levels varied significantly (un-adjusted p-values ≤ 0.05) from the healthy controls. 2265 mapped IDs were uploaded to the Ingenuity pathway analysis suite (IPA) where 1190 known genes were identified as being differentially regulated between groups. An FDR ≤ 5% and fold change limit of +/- 4.0 further refined the data set to identify the 72 most highly and significantly differentially regulated genes in the spinal cord at the clinical peak of disease in MBP induced EAE in the Lewis rat.

Repositories


GEO

GSE39119

ArrayExpress

E-GEOD-39119

BioProject

PRJNA170051

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Contact


Hayley Inglis
Hayley Ruth Inglis

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