Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 34
Release date: Jul 30 2008
Last update date: Jul 31 2017
Access: Public
Chemicals: Toluene
Dataset link Coordinated Changes in Xenobiotic Metabolizing Enzyme Gene Expression in Aging Male Rats: Brown Norway and F344

Experimental Protocol


Brown Norway rats: Analysis of gene expression profiles for XMEs in male Brown Norway rats 4, 12, and 24 months old. Rats were exposed to 1g/kg toluene by oral gavage, and sacrificed after 4 hours. Total RNA was isolated from liver samples and gene expression analyzed using Affymetrix Rat 230 2.0 full-genome GeneChips. Data from 18 samples, with three rats in each of the control age groups and dosed age groups, were analyzed. F344 rats: Analysis of gene expression profiles for XMEs in male F344 6, 11, 18, and 24 months old. Total RNA was isolated from liver samples and gene expression analyzed using Affymetrix Rat 230 2.0 full-genome GeneChips. Data from 16 samples, with four rats in each of the 4 age groups, were analyzed.

Repositories


GEO

GSE11097

ArrayExpress

E-GEOD-11097

BioProject

PRJNA106975

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Contact


Hongzu Ren