Dataset features

Specifications


Application: RNA-seq analysis
Number of samples: 128
Release date: Jun 29 2018
Last update date: Nov 20 2018
Access: Public
Diseases: Alzheimer Disease, Dementia, Vascular Diseases, Dementia, Vascular
Dataset link Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain

Experimental Protocol


Hippocampus and cortex were selected because they represent tissues affected in AD at early and late stages, respectively (Matarin 2015, Mastrangelo 2008). Brain tissue samples were obtained from male Trem2 knockout (KO) and wild type (WT) control mice at two time points: 4 months and 8 months. These time points span the onset and late disease stages in well established AD mouse models (Matarin 2015). RNA-Seq was used to profile the transcriptomes for each sample. Two technical replicates were obtained for each sample.

Repositories


GEO

GSE104381

ENA

SRP119064

BioProject

PRJNA412500

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Contact


Guillermo Carbajosa