Computational protocol: Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling

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Protocol publication

[…] We investigated five dyslexia case–control samples from Salzburg (Austria), Zurich (Switzerland), Marburg (Germany), Munich (Germany) and Maastricht (The Netherlands). The whole sample set was comprised of 927 dyslexia cases and 1096 controls. Besides case–control status, data on eight language-relevant cognitive processes were available for all individuals, with the exception of the Marburg-controls (N=1552, ). These eight cognitive processes include word reading, word spelling, phonological awareness (phoneme deletion), phonological coding (non-word reading), auditory short-term memory (digit span) and rapid naming (letters, digits, pictures). Details of the phenotypic measures are provided in .Genotyping of the variants of interest was carried out on the Sequenom MassArray system (Sequenom, San Diego, CA, USA). Primer sequences and standard assay conditions are available upon request.Association analyses were performed using PLINK. Logistic regression was used for case–control analyses, and linear regression was used for quantitative trait analyses. To avoid false-positive results due to possible population stratification in our sample set, we performed an inverse variance weighted fixed effects meta-analysis using the R-library rmeta (http://www.r-project.org/). […]

Pipeline specifications

Software tools PLINK, rmeta
Application GWAS
Organisms Homo sapiens
Diseases Central Nervous System Diseases
Chemicals Zinc