Dataset features

Specifications


Application: RNA-seq analysis
Number of samples: 63
Release date: Nov 21 2016
Last update date: Nov 28 2018
Access: Public
Genes: CD8A
Dataset link Partially exhausted CD8+ T cells are associated with clinically beneficial response to Teplizumab in new onset type I diabetes (bulk RNA-seq of sorted CD8+ T-cells)

Experimental Protocol


We performed bulk RNA-seq on 63 sorted CD8+ T-cell samples from 3 responders at visit month 6 (N = 34, 15, 14); we sorted cells with and without EOMES-associated inhibitory receptors (TIGIT, KLRG1); prior to RNA extraction, cells were either unstimulated, stimulated with anti-CD3 and anti-CD28, or stimulated with additional PVR-Fc treatment.

Repositories


GEO

GSE85530

ENA

SRP081574

BioProject

PRJNA338796

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Contact


Scott Presnell