Computational protocol: Increased Serum Levels of Oxytocin in ‘Treatment Resistant Depression in Adolescents (TRDIA)’ Group

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Protocol publication

[…] Statistical analyses were performed using the software package SPSS ver. 21.0 for Macintosh (IBM, Armonk, NY) and G*Power3. Fisher’s exact test was used for categorical variables. Student's t-test and the Mann-Whitney U-test were used for the comparisons of continuous variables between pairs of groups. Levene's test was used to determine whether the variables showed equal variance. A one-way analysis of variance (ANOVA) followed by Tukey's multiple comparison was used for comparisons of age in the TRDIA and non-TRDIA groups and the controls. The Kruskal-Wallis test was used for the comparisons of the serum levels of OXT in the TRDIA and non-TRDIA groups and controls. We used Pearson's and Spearman's correlation coefficients and a forced entry multiple regression analysis to detect correlations between serum OXT levels and clinical variables. Statistical significance was set at p<0.05 (two-tailed) with power (1-β) = 0.80. The Wilcoxon Mann-Whitney test with 37 total pediatric depression samples and 25 control samples, 10 TRDIA samples, 27 non-TRDIA samples would have enabled us to detect the following effect sizes: total pediatric depression vs. controls, d = 0.73 (medium-to-large); TRDIA vs. non-TRDIA, d = 1.07 (large); non-TRDIA vs. controls; d = 0.79 (medium to large); TRDIA vs. controls, d = 1.08 (large). […]

Pipeline specifications

Software tools SPSS, G*Power
Application Miscellaneous
Organisms Homo sapiens
Diseases Genetic Diseases, Inborn
Chemicals Oxytocin