|Application:||Gene expression microarray analysis|
|Number of samples:||16|
|Release date:||Oct 15 2016|
|Last update date:||Aug 23 2018|
|Diseases:||Carcinoma, Carcinoma, Squamous Cell, Cell Transformation, Neoplastic, Neoplasm Metastasis, Neoplasms|
|Dataset link||Cell type-specific chromatin states differentially prime squamous cell carcinoma tumor-initiating cells for epithelial to mesenchymal transition [expression 1]|
KrasG12D and YFP expression combined with deletion of p53 were induced in Hair Follicle Stem cells (SCs) and their progeny using Lgr5CREER/KRasG12D/p53fl/fl/Rosa-YFP mice, and in the Intra Follicular Epidermis and the infundibulum using K14CREER/KRasG12D/p53fl/fl/Rosa-YFP mice by intraperitoneal tamoxifen injection. Cells were harvested and compared prior oncogenic hits and in fully grown tumours.