Computational protocol: Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans

Similar protocols

Protocol publication

[…] The crystal structure of rat COMT was used as a template (pdb-code 1h1d) to build a model of the catechol-O-methyltransferase domain of the human LRTOMT2 (). The WHAT IF-server (http://swift.cmbi.ru.nl) was used for modeling. Energy minimization and analysis were done with Yasara (http://www.yasara.org). For the modeled region (residues 79-290) of LRTOMT2, there is 39% sequence identity with rat COMT. The alignment and a rotating figure of the model is available on http://www.cmbi.ru.nl/~hvensela/catechol. […]

Pipeline specifications

Software tools WHAT IF, YASARA
Application Drug design
Organisms Homo sapiens