Computational protocol: Validation of the Turkish version of the Liverpool Oral Rehabilitation Questionnaire version 3 (LORQv3) in prosthetically rehabilitated patients with head and neck cancer

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Protocol publication

[…] Descriptive data included mean values and standard deviation for continuous variables and proportions for categorical variables. Face and content validity of the questionnaire were examined by the expert panel prior to the validation. Reliability was assessed in two ways: internal consistency reliability and test–retest reliability. Internal consistency was evaluated with Cronbach's alpha coefficient. Test- retest reliability, with a 7–14-day interval between test and retest, was measured by the kappa coefficient weighted by applying standard weights according to the number of categories in error. Internal consistency is considered good if Cronbach’s alpha approximates to 0.70 but does not exceed 0.90, which implies the presence of redundant items []. Kappa values between 0.00 and 0.20 are considered poor; those between 0.21 and 0.40, fair; those between 0.41 and 0.60, moderate; those between 0.61 to 0.80, good; and those between 0.81 and 1.00, very good [].Criterion validity was assessed by the following hypotheses: (1) Significant negative correlations (Spearman’s rank order correlation coefficient) would be found between items of the LORQv3 and the UW-QOL v4 that assess the related function. (2) Items of the LORQv3, assessing the psychosocial impact of prostheses and the participant’s denture satisfaction would be more correlated with the items in the physical subscale of the UW-QOL v4 than the terms in the social–emotional function subscale of the UW-QOL v4. Interpretation of correlation coefficients was as follows: r ≤0.49: weak relationship; 0.50 ≤ r ≤0.74: moderate relationship; and r ≥0.75: strong relationship [].Construct validity was evaluated by comparing item scores of the LORQv3 among patient groups who received different oral rehabilitations. It is known that postoperative radiation therapy and the extent of therapy are most important variables affecting HRQOL in maxillectomy patients with prosthetic obturation [, , , ]. Oral cancer survivors had more problems regarding social eating, social contact, and opening the mouth than nasopharyngeal cancer survivors []. Thus, patients were classified into three groups: 15 patients rehabilitated with maxillary obturator prostheses after maxillectomy; 23 patients rehabilitated with maxillary obturator prostheses who were treated with surgery plus postoperative radiotherapy, with or without chemotherapy; 8 nasopharyngeal cancer patients without maxillary defects wearing a conventional upper denture, who served as a control group. We hypothesized that: (1) Maxillary obturator patients would report higher scores on the items related to facial appearence, speaking, and dissatisfaction with the upper denture than nasopharynx cancer patients wearing conventional upper dentures; (2) Maxillary obturator patients treated with surgery plus radiotherapy with or without chemotherapy would be more likely to report functional and emotional problems with their upper prosthesis than those who had been treated with surgery alone and who had been diagnosed with nasopharyngeal cancer.In order to compare the socio-demographic and clinical characteristics of patient groups, continuous data were analyzed by means of analysis of variance (one-way ANOVA), Kruskal-Wallis, Mann- Whitney U and independent- sample t-tests. The continuous variables were tested for normal distribution by the Shapiro-Wilk test. Categorical variables were examined using the chi-square test. Fisher’s exact test was used for variables with expected counts <5. To verify differences on LORQv3 scores between groups, we used the non-parametric Kruskal-Wallis test with Dunn's multiple comparison post test. Statistical analyses were performed with SPSS Statistics version 19.0.0 (IBM Corporation, Somers, NY, USA). Linear weighted kappa was calculated according to the procedure given on the website: […]

Pipeline specifications

Software tools SPSS, VassarStats
Application Miscellaneous
Organisms Homo sapiens, Meleagris gallopavo
Diseases Head and Neck Neoplasms, Neoplasms