Computational protocol: Refraction during incipient presbyopia: The Aston Longitudinal Assessment of Presbyopia (ALAP) study

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Protocol publication

[…] To ensure the recruited sample size was appropriate for repeated measures ANOVA analysis (within and between interaction), an effect size (f) of 0.25, an error probability (α) of 0.05 and required power (1 − β) of 0.80 was inputted into G*Power 3 for 6 repeat measurements amongst 2 groups, which produced an overall sample size of 20. [...] All data from right eyes only were tested for normality using the Shapiro–Wilk test (SigmaPlot; Systat Software Inc., California, USA). The gender distribution within the emmetropic and myopic groups was compared using a Chi-Square Test. Differences between the baseline age of the emmetropic and myopic groups were determined by a t-test (SPSS; SPSS Inc., Illinois, USA). In order to determine whether changes in amplitude of accommodation and refraction vectors were significant over the 2.5 year period, repeated measures analysis of variance (ANOVA) testing was performed, comparing the effect of time (within-subject variable) and refractive group classification (between-subject variable). Linear regression analysis was performed to determine whether the baseline MSE, change in amplitude of accommodation and refraction vectors was significantly correlated with baseline age and whether the change in amplitude of accommodation was significantly correlated with the change in refraction after 30 months. […]

Pipeline specifications

Software tools G*Power, SigmaPlot, SPSS
Organisms Homo sapiens
Diseases Astigmatism, Presbyopia, Refractive Errors