|Application:||ChIP-seq analysis, WGS analysis|
|Number of samples:||71|
|Release date:||Mar 20 2017|
|Last update date:||Oct 24 2018|
|Diseases:||Leukemia, Neoplasms, Disorders of Sex Development, Leukemia, Myeloid, Acute|
|Dataset link||Genome-wide mapping of histone H3 lysine 9 dimethylation in normal myeloid cells and acute myeloid leukemia|
ChIP-Seq with antibodies against H3K9me2 was used with normal human granulocytes (2 samples), CD34+ hematopoietic progenitors (2 samples), K562 cells (2 intact samples and 2 samples treated with G9a inhibitor UNC0638), and primary myeloblasts from 8 different acute myeloid leukemia samples. Each H3K9me2 ChIP-seq was repeated twice. In addition, control experiments for antibody specificity were conducted with ChIP input DNA (16 samples), and ChIP-seq with antibodies against histone H3K9me3 (4 samples), histone H3K4me2 (1 sample), and nonmodified histone H3 C-tail (2 samples).
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