Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 11
Release date: Sep 5 2013
Last update date: Nov 9 2017
Access: Public
Diseases: Substance-Related Disorders
Dataset link Protein sets define disease states and predict in vivo effects of drug treatment [Liver B]

Experimental Protocol


Male C57BL/6 mice (age 6 wks) were fed for 12 weeks with high-fat diet (HFD) and than distributed into 3 groups. Mice were than fed over 3 weeks with HFD without compound ('HFD'), HFD with 4 mg/kg/d rosiglitazone ('HFD_RSG') or with 100 mg/kg/d amorfrutin 1 ('HFD_A1') [GSE38853; Liver A]. In parallel, mice were fed for 15 weeks with low-fat diet (LFD) as healthy control subjects. In addition, a group of mice was treated with 37 mg/kg/d amorfrutin 1 during the whole 15 weeks of HFD feeding ('HFD+A1prev'). Finally, LIVER tissue was harvested and RNA extracted. --> 3-4 biological replicates (2 mice per each replicate, RNA of 2 mice always pooled). liver_HFD_*A and _*B samples are from the same biological source material, but the cRNA preparation and hybridization to Illumina arrays were performed at different days (i.e. technical repeats).

Repositories


GEO

GSE38854

ArrayExpress

E-GEOD-38854

BioProject

PRJNA169103

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Contact


Christopher Weidner