|Application:||Gene expression microarray analysis|
|Number of samples:||56|
|Release date:||Dec 22 2014|
|Last update date:||Aug 23 2018|
|Diseases:||Colitis, Ulcerative, Crohn Disease|
|Dataset link||Molecular patterns in human ulcerative colitis and correlation with response to infliximab|
We studied 56 colon biopsies from patients with colitis, including 43 with UC, characterizing the clinical and histological features, and defined the mRNA phenotype with Affymetrix expression microarrays. We measured the expression of previously defined pathogenesis-based transcript sets representing effector T cells, macrophages, IFNG effects, and parenchymal injury response and dedifferentiation. We also studied 48 microarray files from human colon biopsies from the Gene Expression Omnibus database, classified by response to infliximab therapy to look for molecular changes that predict unresponsiveness.