Computational protocol: Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Somatosensory Amplification and Nocebo Responses

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Protocol publication

[…] All data are expressed as mean ┬▒SEM. Immunological, neuroendocrine, cardiovascular parameters, as well as CsA levels in whole blood were analyzed using repeated-measures analysis of variance (ANOVA). Psychological characteristics as well as behavioral parameters were compared with univariate analysis of variances (ANOVA) followed by Bonferroni post-hoc tests. Pearson correlations were measured, using PASW statistics version 18 (SPSS, Chicago, USA). Allele and genotype distributions did not deviate from Hardy-Weinberg equilibrium. To analyze association of all variants, Fisher's exact test (allelic association) was calculated with PLINK . If not stated otherwise, all p-values are asymptotic, two-sided and corrected for multiple testing. The significance-level was set at p<0.05. […]

Pipeline specifications

Software tools SPSS, PLINK
Applications Miscellaneous, GWAS
Organisms Homo sapiens