Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 28
Release date: Jun 18 2014
Last update date: Jul 26 2018
Access: Public
Diseases: Fibrosis, Inflammation, Glomerulonephritis, Membranous
Chemicals: Creatinine
Dataset link Expression data from biopsies of TGP patients

Experimental Protocol


The study population was derived from renal allograft biopsies diagnosed with TGP at Montefiore Medical Center, Bronx, NY from January 2009 to December 2012. All biopsies were clinically indicated for elevated creatinine or proteinuria. A retrospective chart review was conducted to record clinical, demographic, immunological, and histopathological parameters and graft outcomes. Graft loss was defined as requiring dialysis and/or retransplantation during follow-up. Of the 525 patients who underwent clinically indicated transplant kidney biopsies, 52 patients (10%) had diagnosis of TGP. Median follow up time after the biopsy was 23 months (range, 1-46). Seventeen patients (32%) lost their allografts (defined by return to dialysis or re-transplantation) at a median time of 16 months (range, 1-44). A subgroup of patients who were enrolled in the IRB-approved “Immune Monitoring Study” and had clinically indicated biopsy samples were included in the analysis. A total of 28 biopsy samples (8 graft loss and 20 functioning allograft) were used for gene expression profiling.

Repositories


GEO

GSE58601

ArrayExpress

E-GEOD-58601

BioProject

PRJNA252967

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Contact


Pilib Ó Broin
Pilib Ó Broin