|Dataset type:||Expression profiling by high throughput sequencing, Genome binding/occupancy profiling by high throughput sequencing|
|Number of samples:||31|
|Release date:||Jan 14 2019|
|Last update date:||Feb 14 2019|
|Dataset link||Xist RNA antagonizes the chromatin remodeler, BRG1, from the inactive X chromosome|
The role of Xist RNA as a safeguard of the Xi chromsome during X-chromosome inactivation (XCI) was explored by performing DNA accessibility assay (ATAC-seq) in WT and Xist-KO fibroblast cells. Xist's role in repulsion of the catalytic subunit of SWI/SNF complex, BRG1, was determined by native chromatin immunoprecipitation (ChIP-seq) in these cells. Xist's role on gene regulation during XCI maintenance was investigated by genome-wide expression profiling (RNA-seq).