Computational protocol: The role of rs2237781 within GRM8 in eating behavior

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Protocol publication

[…] Prior to statistical analysis, non-normally distributed parameters were logarithmically transformed to approximate normal distribution. Genetic associations with restraint, disinhibition and hunger were assessed using linear regression models (data analyzed as continuous variables) using age, gender, BMI, and current smoking as covariates for the Sorbs and German cohort. Significant effects in the Sorbs were adjusted for relatedness structure estimated on the basis of genome-wide SNP array data. The Amish data were adjusted for age, sex, and relatedness structure. Current smoking was defined as follows: current smokers versus ever smokers + never smokers. P-values <0.05 were considered to provide nominal evidence for association. Two-sided P-values are reported. Statistical analyses were performed using SPSS statistics 20 version 20.0.1 (SPSS, Inc., Chicago, IL). For adjustments regarding relatedness structure in the discovery cohort, we used a mixed-model approach implemented in the GenABEL package of the statistical software environment R (http://www.r-project.org, Amin et al. ). A meta-analysis was performed using METAL (http://www.sph.umich.edu/csg/abecasis/metal/). Study specific P-values and effect directions were converted into a Z-statistics and weighted with sample size of each study. […]

Pipeline specifications

Software tools SPSS, GenABEL
Applications Miscellaneous, GWAS
Organisms Homo sapiens
Diseases Alcoholism