Computational protocol: Obligatory and facultative brain regions for voice-identity recognition

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Protocol publication

[…] For 56 patients structural high-resolution MRI scans and for two patients CT scans were available. MRI scans were acquired on a 3 T Siemens MRI system (Siemens Trio® or Verio® system, Siemens Medical Systems) including 3D T1-weighted (1 mm3 isotropic voxels) and FLAIR images. Lesions were manually delineated in all three planes (axial, coronal, sagittal) on each slice of the T1 images using MRIcron (). The FLAIR images served as a reference. Lesion delineation was performed by an experienced neurologist (H.O.) who was blind to the individual patient’s performance in the behavioural test battery. The T1 images were transformed into standard stereotactic space (MNI) using SPM8 ( The unified segmentation approach was applied () and the estimation of normalization parameters was restricted to healthy tissue using the predefined lesion mask (cost function masking, ). The CT images (3–5 mm slice thickness and ≤0.5 mm in-plane resolution) were analysed by the same normalization package (‘clinical toolbox’; These images were resampled to yield the same 1 mm3 isovoxel resolution as the MRI images. [...] Statistical maps were thresholded at voxel-wise P < 0.01. They were then corrected for multiple comparisons based on cluster size with respect to 1000 permutations in which behavioural scores were randomly reassigned (; ). After permutation, clusters with a corrected P < 0.05 were considered significant. We applied the same significance threshold for whole-brain and region of interest analyses. For the behavioural analyses, we applied a significance threshold of P < 0.05. We used Pearson correlation to compute correlations and ANOVAs or Mann-Whitney U-tests to assess group differences as implemented in IBM SPSS Statistics for Windows, Version 24 (Armonk, NY: IBM Corp.). When group variances were equal (tested with Levene’s test), we used ANOVAs, and if not, we applied Mann-Whitney U-tests. For significant lesion-behaviour associations and behavioural group differences, effect sizes d were calculated using the following equation based on the T-statistics (t) and the number of participants (n) d = 2 t / √n. […]

Pipeline specifications

Software tools MRIcron, SPM, SPSS
Applications Miscellaneous, Magnetic resonance imaging
Organisms Homo sapiens
Diseases Brain Diseases