Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 8
Release date: Jun 4 2015
Last update date: Feb 2 2018
Access: Public
Diseases: Leukemia, Megakaryoblastic, Acute, Primary Myelofibrosis
Dataset link Expression data from Lineage-c-Kit+Sca-1+ (LSK) and megakaryocyte/erythroid progenitor (MEP) cells isolated from WT, Ezh2Δ/Δ, JAK2V617F, and JAK2V617F/Ezh2Δ/Δ mice

Experimental Protocol


The total bone marrow cells isolated from Cre-ERT2, Ezh2flox/flox;Cre-ERT2, JAK2V617F;Cre-ERT2 and JAK2V617F;Ezh2flox/flox;Cre-ERT2 mice were transplanted into lethally irradiated CD45.1+ wild-type recipient mice. As we deleted Ezh2 at four weeks post transplantation, we performed gene-expression analysis of LSKs and MEPs isolated from the recipient mice at 2 months post transplantation.

Repositories


GEO

GSE69498

ArrayExpress

E-GEOD-69498

BioProject

PRJNA285745

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