Dataset features

Specifications


Application: Peptide array analysis
Number of samples: 257
Release date: Jul 1 2018
Last update date: Jul 3 2018
Access: Public
Diseases: Arthritis, Rheumatoid, Cardiovascular Diseases
Chemicals: Cholesterol
Dataset link Plasma Adiponectin Levels are Associated with Circulating Inflammatory Cytokines in Autoantibody Positive First-Degree Relatives of Rheumatoid Arthritis Patients

Experimental Protocol


We analyzed samples from 144 first-degree relatives (FDRs) of RA probands, of whom 23 were positive for anti-cyclic citrullinated peptide antibody and/or ≥ 2 rheumatoid factor isotypes (IgM, IgG or IgA). We called this phenotype the ‘high risk autoantibody profile (HRP)’ as it has been shown in prior work to be >96% specific for future RA. We measured adiponectin, cytokines/chemokines, and high-sensitivity C-reactive protein (hsCRP). Using linear mixed effects models, we evaluated interaction between HRP positivity and adiponectin on inflammatory markers, adjusting for age, sex, ethnicity, body mass index, pack-years smoking, and use of cholesterol-lowering medications.

Repositories


GEO

GSE114043

BioProject

PRJNA461100

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Contact


Jan Hughes-Austin