|Application:||Peptide array analysis|
|Number of samples:||257|
|Release date:||Jul 1 2018|
|Last update date:||Jul 3 2018|
|Diseases:||Arthritis, Rheumatoid, Cardiovascular Diseases|
|Dataset link||Plasma Adiponectin Levels are Associated with Circulating Inflammatory Cytokines in Autoantibody Positive First-Degree Relatives of Rheumatoid Arthritis Patients|
We analyzed samples from 144 first-degree relatives (FDRs) of RA probands, of whom 23 were positive for anti-cyclic citrullinated peptide antibody and/or ≥ 2 rheumatoid factor isotypes (IgM, IgG or IgA). We called this phenotype the ‘high risk autoantibody profile (HRP)’ as it has been shown in prior work to be >96% specific for future RA. We measured adiponectin, cytokines/chemokines, and high-sensitivity C-reactive protein (hsCRP). Using linear mixed effects models, we evaluated interaction between HRP positivity and adiponectin on inflammatory markers, adjusting for age, sex, ethnicity, body mass index, pack-years smoking, and use of cholesterol-lowering medications.