Computational protocol: Optical Coherence Tomography Reveals Distinct Patterns of Retinal Damage in Neuromyelitis Optica and Multiple Sclerosis

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Protocol publication

[…] Cohort differences were analyzed using Kruskal Wallis test for age of all groups and Mann-Whitney-U tests (MWU) for time since diagnosis and time since last ON of the NMOSD and the MS group. To investigate differences in OCT measures between the different cohorts and between ON and NON eyes, generalized estimation equation models (GEE) with working correlation matrix ‘exchangeable’ were used accounting for within-patient inter-eye dependencies. In all GEE models, diagnosis was used as independent variables and OCT parameters as dependent variables. To account even for potential effects of demographic variables we also corrected for age and gender. The monocular association between GCL and visual function was tested using linear regression models (LR) with GCL as independent and visual function as dependent variable with no further covariates. For subgroup analyses (ON or NON eyes) only the respectively matched HC eyes were included in the analyses, resulting in different, but exactly eye-wise matched cohorts.All statistical analyses were performed with SPSS 20 (IBM SPSS, NY, USA), all graphical figures were created using R (basic R version 2.15.2 including the ggplot2 package). Statistical significance was achieved at p<0.05. All tests should be understood and interpreted as constituting exploratory data analysis in such way that no previous power calculation or adjustments for multiple testing were made. […]

Pipeline specifications

Software tools SPSS, Ggplot2
Application Miscellaneous
Organisms Homo sapiens
Diseases Multiple Sclerosis, Neuromyelitis Optica, Optic Neuritis, Retinal Diseases, Multiple Sclerosis, Relapsing-Remitting