Computational protocol: Retrospective Analysis of Structural Disease Progression in Retinitis Pigmentosa Utilizing Multimodal Imaging

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Protocol publication

[…] Measurements were obtained from SD-OCT and fundus SW-AF images recorded for all visits of each patient in the cohort. EZ-line width and horizontal and vertical hyperfluorescent ring diameters were measured twice by the first author (T.C.) one week apart (Fig. ). Progression rates and test-retest reliability of measurements were calculated as previously described. Reliability was assessed with descriptive statistics for differences between test-retest values and by calculating intraclass correlation coefficients of test-retest measurements. Pearson correlations were used to compare structural measurements for the initial visit. Progression rates were estimated using linear mixed models with random intercepts and slopes, where the random slope for a subject was his/her estimated change over time. Left and right eyes were compared by calculating the absolute difference between the random slopes and using descriptive statistics to quantify the asymmetry within various percentiles. Linear mixed models were fit for other factors of interest such as: age, gender, mode of inheritance, and initial baseline measurement. Initial baseline measurement was assessed as a dichotomized (Table ) and continuous (Table ) variable. The models which were fit included time, the factors of interest, and the interaction of this factor with time. Statistical analyses were done using R version 3.3.1, and also utilizing utilized nlme and lme4 sub packages (Vienna, Austria). […]

Pipeline specifications

Software tools nlme, lme4
Application Mathematical modeling
Organisms Homo sapiens
Diseases Retinitis Pigmentosa