Computational protocol: Time-dependent functional role of the contralesional motor cortex after stroke

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Protocol publication

[…] Magnetic resonance images were acquired in a clinical routine setting within the first 2 days after stroke for all patients on a 1.5 T MRI scanner using standard sequences (Philips, Guildford, UK). Individual lesion maps were created based on diffusion-weighted images (DWI), using ITK-SNAP (www.itksnap.org). After determination of individual lesion volumes, DWI images and lesion maps were first co-registered to individual T2-weighted images and subsequently normalized to the T2-weighted MNI template implemented in Statistical Parametric Mapping (SPM8, http://www.fil.ion.ucl.ac.uk/). Lesions located in the right hemisphere (n = 5) were flipped along the mid-sagittal plane, so all lesions are shown in the left hemisphere.To assess whether stimulation effects were associated with lesion location, voxel lesion symptom mapping (VLSM) was performed using the non-parametric mapping (NPM) software package () with correction for multiple comparisons by the non-parametric permutation tests, as recommended for medium-sized samples (, ). […]

Pipeline specifications

Software tools ITK-SNAP, SPM
Application Magnetic resonance imaging
Organisms Homo sapiens
Diseases Stroke