Computational protocol: Leptin Receptor Gene Variant rs11804091 Is Associated with BMI and Insulin Resistance in Spanish Female Obese Children: A Case-Control Study

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Protocol publication

[…] All continuous variables were expressed as mean ± standard error of the mean (SEM). Cholesterol, insulin, HOMA-IR, MMP-9, and tPAI-1 were normalised using log-transformation. Comparisons between normal-BMI and children with obesity variables were assessed using the Student’s t-test for unpaired samples. The genotypic relative risk was assessed using logistic regression analysis under an additive model with Bonferroni correction comparing the obese and the normal-BMI group in the whole population and separately by sex. Linear or logistic regression analyses were performed to estimate the association of each SNP with parameters linked to obesity and inflammation and CVD risk biomarkers. Significance was considered at the level of p < 0.05. The statistical analyses were performed with IBM-SPSS Statistics 20 (Armonk, NY, USA) and PLINK version 1.07 []. […]

Pipeline specifications

Software tools SPSS, PLINK
Applications Miscellaneous, GWAS
Organisms Homo sapiens
Diseases Cardiovascular Diseases, Metabolic Diseases
Chemicals Cholesterol, Glucose