|Application:||Gene expression microarray analysis, miRNA array analysis|
|Number of samples:||11|
|Release date:||Dec 30 2010|
|Last update date:||May 7 2014|
|Diseases:||Carcinoma, Hepatocellular, Neoplasms|
|Dataset link||Aberrantly microRNA profiling in cancerous hepatocytes versus normal primary hepatocytes|
Over the past few years, though several studies have uncovered aberrant miRNA expression profiles in HCC compared with matched nonmalignant tissues, the overlap of deregulated miRNAs from different platforms is limited. To solve this problem, we recommend a method that using primary cancer cells or cancer cell lines and nonmalignant primary cells to identify the specific aberrantly miRNA expression profiles in HCC and even in other types of cancer. Here, we identified the aberrantly expressed miRNAs involved in hepatoma through the comparison of miRNA expression profiling in cancerous hepatocytes with that in normal primary human hepatocytes and 37 dysregulated miRNAs were screened out by 2-fold change with a significant difference (P<0.05). Clustering analysis based on 13 miRNAs whose fold changes were over 15-fold change exhibited significantly differential expression pattern between the cancerous and normal hepatocytes.