|Application:||Gene expression microarray analysis|
|Number of samples:||6|
|Release date:||Sep 19 2006|
|Last update date:||Aug 23 2018|
|Dataset link||Searching for Brca1 regulated X-linked genes|
Mutations in breast cancer associated gene-1 (BRCA1) are associated with hereditary breast and ovarian cancers. BRCA1 encodes a tumor suppressor protein that functions in DNA repair, transcriptional regulation, chromatin remodeling, centrosome duplication and checkpoint control, etc.. We were interested in fishing out the genes regulated by Brca1. Three pairs of mammary glands from Brca1 D11/D11;p53+/- mutant and control (p53+/-) mice at three different stages of the mammary cycle were analyzed by microarray for gene expression levels.