Computational protocol: Striatal volume is related to phonemic verbal fluency but not to semantic or alternating verbal fluency in early Parkinson’s disease

Similar protocols

Protocol publication

[…] A 1.5-T scanner (Philips Gyroscan Intera 1.5T CV Novo Dual, Philips Healthcare, Best, the Netherlands) equipped with a SENSE head coil was used to obtain T1- and T2-weighted, diffusion and flair sequences. T1-weighed three-dimensional fast field echo images were obtained in transverse planes with contiguous 1 × 1 × 1 mm voxels, 25 ms echo time, 30° flip angle, and field-of-view 256 × 256 mm yielding at least 160 contiguous slices.The preprocessing of the T1-weighted images were performed with the VBM8 toolbox for SPM (Christian Gaser, University of Jena; and the voxel-wise analyses of the gray matter segments were conducted using SPM8 (Wellcome Department of Cognitive Neurology, London, UK) running in Matlab R2011a (MathWorks, Natick, MA). Total intracranial volumes (TIVs) were obtained from native-space images. The normalization to MNI space was achieved using a high-dimensional DARTEL normalization procedure (Ashburner ). The analyses were conducted using modulated images (1.5 × 1.5 × 1.5 mm voxels) (Ashburner and Friston ), which were smoothed with a 10-mm full width at half maximum (FWHM) Gaussian kernel. The images were thresholded with voxel value 0.1 to include the whole brain and restrict the analyses only to the gray matter.Potential confounding factors (gender, age, handedness, education and TIV in the whole sample; and UPDRS score in PD patients) were analyzed using single variable regression. Age and TIV were associated with local GM volumes and thus included to the multiple regression analyses as nuisance covariates. Also sex had an effect on the local GM volumes, but was not included as a covariate, because of a strong intercorrelation with TIV as men had larger TIV compared to women. The variables of interest included semantic, phonemic, and alternating fluency. The analyses were performed at height threshold of uncorrected p < 0.005, and family-wise error (FWE) corrected cluster-level pfwe < 0.05 was considered statistically significant. The results were visualized by using Mango (version 2.6, […]

Pipeline specifications

Software tools SPM, Mango
Application Magnetic resonance imaging
Organisms Homo sapiens
Diseases Dementia, Parkinson Disease