|Application:||Gene expression microarray analysis|
|Number of samples:||28|
|Release date:||Mar 8 2010|
|Last update date:||Jul 18 2012|
|Diseases:||Acquired Immunodeficiency Syndrome|
|Dataset link||Lymphatic Tissues of Sooty Mangabeys and Rhesus Macaques in Early SIV Infection|
We used affymetrix rhesus microarrays to profile the host transcriptional response to SIV in lymph nodes obtained from SM (Sooty mangabeys, Cercocebus atys)) and RMs ( Rhesus Macaques, Macaca mulatta) in the first two weeks of infection in studies described by Bosinger et al. (GEO accession number GSE16147) of the transcriptional profiles in peripheral blood. We confirm in these genome-wide comparisons that immune activation is a shared feature of early infection in the two species, but show that the breadth of the changes in RMs is much greater than in SMs, with evidence of positive feedback loops that amplify innate and cellular responses in RMs. We also confirm evidence of resolution of immune activation in SMs, but were surprised to find little evidence at the transcriptional level of increased expression of genes that might mediate that resolution. Lastly, we show that as expression of genes involved in host defenses decline in SMs, there is increased expression of defensins that again may represent a species-specific host defense mechanism. Samples: 12 Sooty Mangabeys (uninfected, 14 dpi, and 30 dpi) and 16 Rhesus Macaques (uninfected and 14 dpi).