|Application:||Gene expression microarray analysis|
|Number of samples:||40|
|Release date:||Oct 12 2012|
|Last update date:||Aug 9 2018|
|Diseases:||Lymphoma, Follicular, Lymphoma, B-Cell|
|Dataset link||Gene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor|
10 DLBCL cell lines (7 mutant and 3 wild type EZH2), that were differentially sensitive to GSK126 in proliferation assays, were treated for 72 hours, in duplicate (n=2), with either DMSO (vehicle) or 500nM of GSK126, a potent selective EZH2 inhibitor. EZH2 mutant cell lines are Pfeiffer, KARPAS-422, WSU-DLCL2, SU-DHL-10, SU-DHL-6, DB and SU-DHL-4. EZH2 wildtype cell lines are HT, OCI-LY-19 and Toledo.