Dataset features


Application: SNP array data analysis
Number of samples: 100
Release date: Oct 1 2015
Last update date: Dec 31 2015
Access: Public
Diseases: Brain Neoplasms, Breast Neoplasms, Neoplasms
Dataset link Post-zygotic structural variants in histologically normal breast tissue may predispose to sporadic breast cancer [SET 8]

Experimental Protocol

We studied 282 female breast cancer patients that were assessed as affected by sporadic disease at the time of diagnosis and all underwent mastectomy. In total, 1162 UMs (uninvolved margin tissues), ranging from 1 to 14 UMs per patient, taken outside the location of clinically characterized index primary tumor, were analyzed on Illumina arrays. For each subject, DNA from at least one control tissue was also analyzed, which was predominantly blood DNA, alternatively skin-derived DNA. We also studied primary tumor (PT), or up to 3 primary tumor foci from patients with diagnosis of multifocal disease. This GEO project contains the genotyping profiles (processed and normalized data including Log R Ratio and B allele frequency) for these 1162 UMs used in the study. Information on phenotypes (age at diagnosis, tumor focality, tumor grade, tumor molecular phenotype) is also provided, whenever available. The sixth 100 samples out of 811 experiments runned on platform GPL18224 (Infinium HumanOmniExpressExome)








Chiara Rasi