|Application:||Gene expression microarray analysis|
|Number of samples:||4|
|Release date:||Jul 30 2014|
|Last update date:||Aug 23 2018|
|Diseases:||Leukemia, Neoplastic Syndromes, Hereditary, Leukemia, Myeloid, Acute|
|Dataset link||Association of prognosis of acute myeloid leukemia patients with leukemia stem cell gene signature based on nucleostemin promoter activity|
A mouse acute myeloid leukemia model was generated by introduction of HoxA9/Meis1 to bone marrow cells from a transgenic mouse, in which green florescence protein (GFP) is expressed under the control of particular region of NS promoter (NS-GFP).The leukemia cells were fractionated into 4 subpopulations based on NS-GFP level and c-Kit expression, (a) c-Kit-NS-GFPlow, (b) c-Kit-NS-GFPmiddle, (c) c-Kit+NS-GFPmiddle and (d) c-Kit+NS-GFPhigh cells.