A hand-curated structural database dedicated to protein-protein interactions with known orthosteric modulators. 2P2Idb includes all interactions for which both the protein-protein and protein-ligand complexes have been structurally characterized. A web server provides links to related sites of interest, binding affinity data, pre-calculated structural information about protein-protein interfaces and 3D interactive views through java applets. 2P2Idb represents a structural source of information for scientists from academic institutions or pharmaceutical industries.
Centre de Recherche en Cancerologie de Marseille (CRCM), Marseille, France; Centre National de la Recherche Scientifique (UMR7258), Inserm (UMR1068) & Aix-Marseille University (UM105), Marseille, France