Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 12
Release date: May 28 2018
Last update date: Aug 13 2018
Access: Public
Diseases: Sleep Initiation and Maintenance Disorders, Neoplasms
Chemicals: Tyrosine
Dataset link Deacetylation of miRNA-34a and miRNA-449 induce epithelial-mesenchymal transition and acquired resistance to ALK inhibitors

Experimental Protocol


For in vivo model, mice with established H3122-derived tumors were treated with four doses of ceritinib (control, 75mg/kg, 87.5mg/kg, 100mg/kg) to derive ceritinib-resistant tumors. Xenograft tumors showed initial dose-dependent decrease in tumor volume and subsequently developed acquired resistance within 24-108 days.

Repositories


GEO

GSE81261

BioProject

PRJNA321124

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Contact


Kyoung-Ho Pyo