Computational protocol: SLCO1B1*5 polymorphism (rs4149056) is associated with chemotherapy-induced amenorrhea in premenopausal women with breast cancer: a prospective cohort study

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Protocol publication

[…] The Chi-squared test and Fisher’s exact test were used to compare categorical variables. The Mann-Whitney U-test was performed to compare continuous variables, and Spearman’s correlation coefficient is given, where appropriate. Binary logistic regression was performed to analyze the impact of factors predictive of CIA. Disease-free survival was analyzed using Kaplan-Meier method, with the log-rank test for comparison of subgroups. All analyses were conducted with the IBM SPSS Statistics Package, version 20 (IBM Deutschland GmbH, Ehningen, Germany). In all tests P < 0.05 was considered statistically significant, and all P-values cited were from two-tailed tests.We performed post hoc analysis to estimate the statistical power of the described logistic regression analysis using the G*Power 3.1.9.2 tool []. Two-tailed analysis for prediction of CIA by the rs4149056 polymorphism with an α error of 0.05 revealed a statistical power of 70 % for our sample size. […]

Pipeline specifications

Software tools SPSS, G*Power
Application Miscellaneous
Organisms Homo sapiens
Diseases Breast Neoplasms
Chemicals Cyclophosphamide