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Specifications


Application: Gene expression microarray analysis
Number of samples: 229
Release date: Mar 24 2014
Last update date: Mar 25 2014
Access: Public
Diseases: Leukemia, Lymphoid, Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell
Dataset link Small nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia

Experimental Protocol


This series of microarray experiments contains the gene expression profiles of purified B-cell chronic lymphocytic leukemia (B-CLL) cells obtained from 211 patients (Binet stage A), 6 normal controls from peripheral blood mononuclear cells (BC), and B-cell sub-populations from tonsils (3 naïve B-cells (N), 2 marginal zone (MZ)-like, 3 switched memory (SM) B-cells and 4 germinal center (GC) ). For gene and miRNA expression profiling experiments CLL cells were enriched by negative selection with the EasySep-Human B cell enrichment kit without CD43 depletion (Stem Cell Technologies) using the fully automated protocol of immunomagnetic cell separation with RoboSepTM (Stem Cell Technologies).

Repositories


GEO

GSE46261

ArrayExpress

E-GEOD-46261

BioProject

PRJNA198488

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Contact


Luca Agnelli
Antonino Neri

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