|Application:||Gene expression microarray analysis|
|Number of samples:||29|
|Release date:||Jan 1 2008|
|Last update date:||Mar 17 2012|
|Diseases:||Colonic Diseases, Neoplasms|
|Dataset link||Chromosome 20q amplification regulates in vitro response to Kinesin-5 inhibitor|
A series of colon cancer cell lines was analyzed for gene expression signatures. These gene expression signatures were then correlated with in vitro responsiveness of each cell line to a KSP inhibitor (Kinesin-5i). Transcripts whose expression was correlated with response (>0.5 or <-0.5) were identified as reporters of cellular response to this inhibitor. Reporters were further tested by RNAi for functional role in response to this inhibitor.