Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 29
Release date: Jan 1 2008
Last update date: Mar 17 2012
Access: Public
Diseases: Colonic Diseases, Neoplasms
Dataset link Chromosome 20q amplification regulates in vitro response to Kinesin-5 inhibitor

Experimental Protocol


A series of colon cancer cell lines was analyzed for gene expression signatures. These gene expression signatures were then correlated with in vitro responsiveness of each cell line to a KSP inhibitor (Kinesin-5i). Transcripts whose expression was correlated with response (>0.5 or <-0.5) were identified as reporters of cellular response to this inhibitor. Reporters were further tested by RNAi for functional role in response to this inhibitor.

Repositories


GEO

GSE7969

BioProject

PRJNA100725

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