Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 6
Release date: Sep 1 2015
Last update date: Aug 13 2018
Access: Public
Diseases: Neoplasms
Chemicals: Tyrosine
Dataset link Anti-tumor activity and acquired resistance mechanism of Dovitinib (TKI258) in RET rearranged lung adenocarcinoma

Experimental Protocol


To identify potential mechanisms of acquired resistance to dovitinib, we established LC-2/ad DR cells with acquired resistance to dovitinib by exposing LC-2/ad cells to increasing doses of dovitinib. LC-2/ad DR cells showed strong resistance to dovitinib (IC50> 3 μmol/L). Next, LC-2/ad and LC-2/ad DR cells were subjected to genome-wide gene expression profiling using cDNA microarray.

Repositories


GEO

GSE69226

ArrayExpress

E-GEOD-69226

BioProject

PRJNA284924

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Contact


Kyoung-Ho Pyo