Dataset features


Application: Gene expression microarray analysis
Number of samples: 27
Release date: Mar 12 2015
Last update date: Nov 9 2017
Access: Public
Diseases: Brain Neoplasms, Neoplasms, Osteosarcoma, Mixed Tumor, Malignant
Dataset link Gene expression analyses of primary tumors and metastases, using p53 mouse models

Experimental Protocol

Development of novel osteoblast-specific alteration of a p53 mouse model that forms de novo localized and gross, macroscopic osteosarcoma that mimics the human disease allowing determination of novel genetic alterations involved in OS progression. Gene expression profiling of primary osteosarcomas (OS) and OS metastases to lung and liver. In order to identify genes and pathways that regulate OS metastasis, we performed an initial screen comparing the gene expression profiles of six localized, non-metastatic OS with those of 12 primary OS that produced metastatic lesions. In addition, seven lung metastatic lesion gene expression profiles were compared to those of the primary tumor from which they originated. multiple group comparison








Chad Creighton