Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 60
Release date: Sep 3 2010
Last update date: Oct 29 2018
Access: Public
Diseases: Infection, Trachoma, Chlamydial Pneumonia
Dataset link Expression data from Gambian children with and without the clinical signs of active trachoma: U133 Plus2.0 array

Experimental Protocol


Conjunctival samples from 60 participants were tested on U133 plus 2.0 arrays (40 participants with clinical signs of active trachoma and 20 controls with normal conjunctivas as before). Samples were further sub-divided based on the detection and quantification of ocular Chlamydia trachomatis load by PCR tests. Gene expression was then assessed using differential expression and construction of co-expression networks. The content of the constructed gene lists which were identified as part of a network or differentially expressed were then tested for enrichment using publically available analysis tools to identify biological pathways expressed in the conjunctiva during C. trachomatis infection and disease episodes.

Repositories


GEO

GSE20436

ArrayExpress

E-GEOD-20436

BioProject

PRJNA125609

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Contact


Martin Holland
Martin James Holland

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