Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 328
Release date: Jun 27 2010
Last update date: Oct 29 2018
Access: Public
Diseases: Multiple Myeloma
Dataset link Gene expression profiling of multiple myeloma patients included in the HOVON65/GMMG-HD4 trial

Experimental Protocol


Bone marrow plasma cell samples were obtained from 320 newly diagnosed multiple myeloma patients included in a large multicenter, prospective, randomized phase III trial (HOVON65/GMMG-HD4). Purified myeloma plasma cells samples with a monoclonal plasma cell purity > 80% were used for analysis. To the original set of 320 samples which were used for the hierarchical clustering analysis, 8 CEL-files were added. Out of 328 CEL-files, 290 CEL-files were linked to survival data and were used to generate the 92 gene survival signature. GCRMA was performed on 290 CEL-files to give the values given for the additional 8 CEL-files. The values of the original 320 CEL-files are left unchanged (i.e. GCRMA on the original 320 CEL-files) to allow optimal comparison to the original paper by Broyl et al.

Repositories


GEO

GSE19784

ArrayExpress

E-GEOD-19784

BioProject

PRJNA122113

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Contact


Annemiek Broyl