|Application:||Gene expression microarray analysis|
|Number of samples:||328|
|Release date:||Jun 27 2010|
|Last update date:||Oct 29 2018|
|Dataset link||Gene expression profiling of multiple myeloma patients included in the HOVON65/GMMG-HD4 trial|
Bone marrow plasma cell samples were obtained from 320 newly diagnosed multiple myeloma patients included in a large multicenter, prospective, randomized phase III trial (HOVON65/GMMG-HD4). Purified myeloma plasma cells samples with a monoclonal plasma cell purity > 80% were used for analysis. To the original set of 320 samples which were used for the hierarchical clustering analysis, 8 CEL-files were added. Out of 328 CEL-files, 290 CEL-files were linked to survival data and were used to generate the 92 gene survival signature. GCRMA was performed on 290 CEL-files to give the values given for the additional 8 CEL-files. The values of the original 320 CEL-files are left unchanged (i.e. GCRMA on the original 320 CEL-files) to allow optimal comparison to the original paper by Broyl et al.