Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 127
Release date: Oct 22 2013
Last update date: Aug 9 2018
Access: Public
Dataset link Blockade of thymic stromal lymphopoietin receptor (TSLPR) reduces allergic inflammation in a cynomolgus monkey model of asthma

Experimental Protocol


Animals were dosed weekly with either vehicle (n=8) or TSLPR HuMAb (n=8) for 6 weeks and their responses to A.Suum challenge at baseline, week 2 and week 6 were assessed. One monkey in the aTSLPR-treated group expired during the study for reasons not linked to drug safety and tolerability. BAL fluid samples for all animals were subject to gene expression profiling for pre-challenge, 8h and 24h post-challenge timepoints, at baseline, week 2 and week 6. This amounted to a total of 135 microarrays. Data from 8 animals were excluded as outliers, determined by PCA.

Repositories


GEO

GSE41329

ArrayExpress

E-GEOD-41329

BioProject

PRJNA176555

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Contact


Donavan Cheng