Computational protocol: Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study

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Protocol publication

[…] The data for this investigation were collected through a prospective cohort of participants at risk for type 2 diabetes (T2D), which has been described in detail previously. Briefly, EpiDREAM enrolled a total of 24 872 individuals recruited from 21 countries who were screened for eligibility to enter the DREAM clinical trial. Individuals who were identified as at risk for type 2 diabetes based on family history, ethnicity and abdominal adiposity were screened using a 75-gram oral glucose tolerance test (OGTT). A subset of 1960 DREAM participants received rosiglitazone over follow-up. All participants were between the ages of 18–85 years and were screened between July 2001 and August 2003. We focused on 17 423 subjects from six ethnic groups (South Asian, East Asian, European, African, Latin American, Native North American) having both phenotypic and 50 K gene-centric array information in the EpiDREAM study (). Self-reported ethnicity has been verified in the 17 423 individuals using the eigensoft software (http://genepath.med.harvard.edu/~reich/Software.htm) and 40 individuals were reclassified. The first 10 components from this principal components analysis were retained to adjust for population stratification ().Of the 17 423 participants at baseline, our follow-up analyses included 9 228 participants with complete genotype and phenotype data. Interim and final visits with participants occurred 12–24 months and 36–48 months (median follow-up 3.3 years) after their screening visit, respectively. Participants who were not able to complete in-person clinic visits were contacted through telephone or mail. The EpiDREAM study has been approved by local ethics committees and the study methodology was carried out in accordance with the approved guidelines. Informed consent was obtained from each subject before participating in the study, in accordance with the Declaration of Helsinki. […]

Pipeline specifications

Software tools EIGENSOFT, GenePath
Application Population genetic analysis
Organisms Homo sapiens