The 3C method uses formaldehyde cross-linking to covalently link interacting chromatin segments in intact cells. Cross-linked chromatin is then solubilized and digested with an appropriate restriction enzyme. This is followed by intramolecular ligation of cross-linked fragments.…
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G T A T C G C T A chromoHBM/chromoHBM-3D/chromoHBM-3C

chromoHBM/chromoHBM-3D/chromoHBM-3C

An algorithmic framework, which is based on hierarchical block matrices (HBMs),…

An algorithmic framework, which is based on hierarchical block matrices (HBMs), for topological analysis and integration of chromosome conformation capture (3C) data. We first describe chromoHBM, an…

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G T A T C G C T A InfMod3DGen InfMod3DGen

InfMod3DGen

A Bayesian framework to derive the 3D architecture of a chromosome from…

A Bayesian framework to derive the 3D architecture of a chromosome from 3C-based data. InfMod3DGen can compute an accurate ensemble of 3D chromatin conformations that best interpret the distance…

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G T A T C G C T A r3Cseq r3Cseq

r3Cseq

An R/Bioconductor package for the discovery of long-range genomic interactions…

An R/Bioconductor package for the discovery of long-range genomic interactions from chromosome conformation capture and next-generation sequencing data.

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