Computational protocol: Possible association between haplotypes of the FKBP5 gene and suicidal bipolar disorder, but not with melancholic depression and psychotic features, in the course of bipolar disorder

Similar protocols

Protocol publication

[…] To test for differences in genotypic and allelic distribution, the two-tailed Pearson χ2 test and Fisher’s exact test were used. Chi-square was used for 3 × 2 contingency tables to compare genotypes (three different) between cases and controls. Fisher’s exact test was used for 2 × 2 contingency tables to compare allele frequencies between cases and controls. Two-tailed power analysis was also performed, using Statistica version 8.0 (StatSoft, Tulsa, OK, USA). A demo of the InStat 3 (GraphPad Software, La Jolla, CA, USA) program was used to calculate odds ratios. Linkage disequilibrium between polymorphisms of the FKBP5 gene was examined by pair-wise comparisons of r2 and D’ using Haploview version 4.1 (Broad Institute, Cambridge, MA, USA). The same software was used to haplotype construction using an expectation–maximization algorithm. Correction for multiple testing was performed for multiple comparisons: in haplotype analysis using 10,000 permutations implemented in the Haploview software. Quanto version 1.2.3 with odds-ratio values between 1.1 and 1.4 for two-sided associations was used for power calculations. […]

Pipeline specifications

Software tools Statistica, Haploview
Applications Miscellaneous, GWAS
Organisms Homo sapiens
Diseases Psychoses, Substance-Induced
Chemicals Tacrolimus