Computational protocol: Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

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Protocol publication

[…] The hidden Markov model based sequence searches were conducted using the HMMER software package ( by constructing a model using the jackhmmer tool, and subsequently using the hmmsearch program to search through the entire Uniprot databases of Saccharomyces cerevisiae and human, respectively. Default values were used for these programs. The top-10 matches for human and top-5 hits for yeast are included as . […]

Pipeline specifications

Software tools HMMER, jackhmmer
Application Amino acid sequence alignment
Organisms Homo sapiens, Saccharomyces cerevisiae
Diseases Sleep Disorders, Intrinsic