Computational protocol: A new familial form of a late-onset, persistent hyperinsulinemic hypoglycemia of infancy caused by a novel mutation in KCNJ11

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Protocol publication

[…] The structures of the wild-type and A28V hKir6.2 were predicted by I-TASSER and the rat Kir6.2 (PDB: 5WUA) was used as a template for de novo structure prediction. TM-Align was used to align wild-type and A28V hKir6.2. Predicted structures were generated in Pymol. […]

Pipeline specifications

Software tools I-TASSER, TM-align, PyMOL
Application Protein structure analysis
Organisms Homo sapiens
Chemicals Adenosine Triphosphate, Potassium