Dataset features

Specifications


Application: Gene expression microarray analysis
Number of samples: 18
Release date: Aug 15 2018
Last update date: Nov 14 2018
Access: Public
Diseases: Breast Neoplasms
Dataset link MDA-MB-231 gene expression upon IRE1 RNase inhibition with MKC-8866

Experimental Protocol


A TNBC cell line MDA-MB 231 was treated with the IRE1 Rnase inhibitor for 4, and 24h in normoxic and hypoxic (1% O2) conditions. We aimed to determine effects of inhibiting IRE1 on an early and a later timepoint to have a broader uderstand how IRE1 Rnase effects cells. Recent reports suggest that XBP1s plays a role in controlling the hypoxic stress response in TNBC cells. To find novel hypoxia-specific functions for IRE1 we inhibited the RNase under hypoxic condditions.

Repositories


GEO

GSE99766

BioProject

PRJNA389571

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Contact


Afshin Samali