|Application:||Gene expression microarray analysis|
|Number of samples:||18|
|Release date:||Aug 15 2018|
|Last update date:||Nov 14 2018|
|Dataset link||MDA-MB-231 gene expression upon IRE1 RNase inhibition with MKC-8866|
A TNBC cell line MDA-MB 231 was treated with the IRE1 Rnase inhibitor for 4, and 24h in normoxic and hypoxic (1% O2) conditions. We aimed to determine effects of inhibiting IRE1 on an early and a later timepoint to have a broader uderstand how IRE1 Rnase effects cells. Recent reports suggest that XBP1s plays a role in controlling the hypoxic stress response in TNBC cells. To find novel hypoxia-specific functions for IRE1 we inhibited the RNase under hypoxic condditions.