Computational protocol: Efficacy of intrathecal morphine for postoperative pain management following open nephrectomy

Similar protocols

Protocol publication

[…] The primary outcome measure of this study was the NPS on coughing 24 h postoperatively. Secondary outcome measures were the NPS at 3, 6, 12, 48 and 72 h postoperatively, incidence of side effects including nausea, vomiting, dizziness, headache, pruritus, sedation and respiratory depression, cumulative morphine usage and the use of any additional interventions to manage side effects. Student’s t-test or Mann-Whitney U-test was applied for continuous variables after the normality test (Kolmogorov-Smirnov test). The incidence of complications was compared between groups using the χ2-square test or Fisher’s exact test. A P-value < 0.05 was considered to indicate a significant difference. Data are presented as means ± SD, median (interquartile range (IQR)) or number (percentage).Sample size was calculated based on a study by Nicholson et al. that reported a NPS 24 h postoperatively of 56 (SD 30). For the current study, it was postulated that a 50% reduction in postoperative pain would be clinically relevant. With α = 0.05 and power of 0.8, a sample size of 20 in each group was necessary. All statistical analyses were performed using the Statistical Package for the Social Sciences software, v19.0 (SPSS Inc., Chicago, IL, USA). The sample size calculation was performed with the G*power 3 software (Institut für Experimentelle Psychologie, Dusseldorf, Germany). […]

Pipeline specifications

Software tools SPSS, G*Power
Application Miscellaneous
Diseases Pain Insensitivity, Congenital, Carcinoma, Renal Cell
Chemicals Morphine