Computational protocol: The PDZ-Ligand and Src-Homology Type 3 Domains of Epidemic Avian Influenza Virus NS1 Protein Modulate Human Src Kinase Activity during Viral Infection

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Protocol publication

[…] The kinetic constants were derived by fitting the experimental data to the appropriate rate equations, as detailed in supplementary Information. Curves were obtained by non-linear least squares computer fitting of the data to the equations with the program GraphPad Prism 3.0.All sequence alignments were generated with the tool CLUSTALW (http://www.ebi.ac.uk/Tools/clustalw2/). Similarity searches were performed with the tools BLAST (http://www.expasy.ch/tools/blast/) and PROSITE (http://www.expasy.ch/tools/scanprosite/). Network interaction analysis was performed by STRING (http://string-db.org/). […]

Pipeline specifications

Software tools Clustal W, ScanProsite
Databases PROSITE ExPASy
Application Protein sequence analysis
Organisms Homo sapiens
Diseases Influenza in Birds, Virus Diseases